From its founding in 2001, BioSTL has recognized that facilities, physical infrastructure, and innovation placemaking to accommodate and encourage startups are essential elements of a robust ecosystem. At first, this entailed the research, analysis, and consensus-building to establish priority “nodes" of innovation activity that today are known as the Cortex Innovation Community (in St. Louis’ urban midtown) and 39 North (a world class suburban concentration of agtech and plant science assets). BioSTL later established pioneering shared laboratories for biotech startups – BioGenerator Labs– now in their third and largest iteration. The St. Louis ecosystem now boasts a wide array of coworking and innovation spaces in urban and suburban settings, promoting collaboration and connectivity.